Naproxen Derivative Interaction Properties with ct-DNA
| dc.contributor.author | Akbay, Nuriye | |
| dc.contributor.author | Köksal, Zeynep Şentürk | |
| dc.contributor.author | Tok, Tuğba Taşkın | |
| dc.contributor.author | Baran, Ayşe Uzgoren | |
| dc.date.accessioned | 2025-05-10T14:03:03Z | |
| dc.date.issued | 2019 | |
| dc.department | İstanbul Medeniyet Üniversitesi | |
| dc.description.abstract | Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy.The experimental results revealed the static quenching as a result of groove binding between the naproxen derivativeand ct-DNA. Computational studies were carried out to a deeper understanding of the interactions. Molecular dockingcalculations showed that the interaction between NH and ct-DNA is resulted by groove binding. In addition to spectral data,docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trendsto each DNA isomer. | |
| dc.identifier.doi | 10.15671/HJBC.517481 | |
| dc.identifier.endpage | 184 | |
| dc.identifier.issn | 1303-5002 | |
| dc.identifier.issn | 2687-475X | |
| dc.identifier.issue | 2 | |
| dc.identifier.startpage | 177 | |
| dc.identifier.trdizinid | 375537 | |
| dc.identifier.uri | https://doi.org/10.15671/HJBC.517481 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/tr/yayin/detay/375537 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14730/4666 | |
| dc.identifier.volume | 47 | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.relation.ispartof | Hacettepe Journal of Biology and Chemistry | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.snmz | KA_TR-Dizin_20250302 | |
| dc.subject | Biyokimya ve Moleküler Biyoloji | |
| dc.title | Naproxen Derivative Interaction Properties with ct-DNA | |
| dc.type | Article |
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