Naproxen Derivative Interaction Properties with ct-DNA

Abstract

Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy.The experimental results revealed the static quenching as a result of groove binding between the naproxen derivativeand ct-DNA. Computational studies were carried out to a deeper understanding of the interactions. Molecular dockingcalculations showed that the interaction between NH and ct-DNA is resulted by groove binding. In addition to spectral data,docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trendsto each DNA isomer.