The Role of Systemic Immune-Inflammation Index and Systemic Inflammation Response Index in the Diagnosis of Bell's Palsy

Abstract

Objective: Recent studies showed that Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI) can be used as inflammatory markers. The aim of this study was to determine the prognostic value of SII and SIRI in children with Bell's palsy (BP) disease. Method: This retrospective study included 107 children diagnosed with BP from 2019 to 2022 in institute and an age-and sex-matched 100 healthy control group. A complete blood count was performed for all participants and hemoglobin, erythrocytes, white blood cell (WBC), absolute neutrophil count (ANC), lymphocytes, and platelet counts were measured. The platelet-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR), SII and SIRI values were calculated with the formula. Results: The male-to-female ratio was 54/53 in patient and 42/58 in the control groups. In estimation of BP, area under the curve was 0.78 for WBC [95% confidence interval (CI): 0.72-0.84, p<0.0011, 0.80 for ANC [(95% CI: 0.75-0.86), p<0.0011, 0.59 for absolute lymphocyte count [(95% CI: 0.51-0.67), p=0.2581, 0.70 for NLR [(95% CI: 0.62-0.77), p<0.0011, 0.77 for SII [(95% CI: 0.71-0.84), p<0.0011 and for SIRI 0.68 [(95% CI: 0.61-0.76), p=0.0011. When the markers were analyzed according to the most appropriate cut-off values in the prediction of BP, the best markers were determined as WBC, ANC, SII and SIRI (p<0.05). Conclusion: BP has an inflammatory component. The SII and SIRI value can indicate an inflammatory condition in these patients. It may be used as an indicator marker in BP.