Antibacterial Activity of a Series Engineering Nanoparticles Against Oral Anaerobic Periodontal Pathogens Species in Vitro

Abstract

Objective: Periodontal disease is an essential phenomenon in human health. Oral pathogens can cause severe break which may show the way to serious issues in human disease like chronic obstructive pulmonary disease and cardiovascular diseases. Therefore, the aim of this study is to evaluate the antibacterial effect of a series nanoparticles on oral pathogens.Methods: In this study, antibacterial activity of a series of nanoparticles such as MWCNT, CuO2, CaCO3, SiO2, Al2O3, MgO and ZrO2 against oral pathogens such as Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) was demonstrated. We evaluated the bactericidal effect of the nanoparticles to perio pathogens by measuring the inhibitor zone region. Antimicrobial experiments were conducted in five replicates.Results: As a result, we confirmed that engineering nanoparticles exhibited good bactericidal activity. SiO2 nanoparticle was the most effective on Pg. CaCO3 nanoparticle was the most effective on Aa. The order of the nanoparticle types in which the Pg is most sensitive is SiO2> MgO> Al2O3> ZrO2> CuO> MWCNT> CaCO3. For Aa order is CaCO3> SiO2>MgO> ZrO2> CuO> MWCNT> Al2O3.Conclusion: Our results suggest that engineering nanoparticles have a significant inhibitory effect on Aa and Pg. And, these effects are increased with increasing concentrations of nanoparticles. These results can be further clarified with new studies

Objective: Periodontal disease is an essential phenomenon in human health. Oral pathogens can cause severe break which may show the way to serious issues in human disease like chronic obstructive pulmonary disease and cardiovascular diseases. Therefore, the aim of this study is to evaluate the antibacterial effect of a series nanoparticles on oral pathogens.Methods: In this study, antibacterial activity of a series of nanoparticles such as MWCNT, CuO2, CaCO3, SiO2, Al2O3, MgO and ZrO2 against oral pathogens such as Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) was demonstrated. We evaluated the bactericidal effect of the nanoparticles to perio pathogens by measuring the inhibitor zone region. Antimicrobial experiments were conducted in five replicates.Results: As a result, we confirmed that engineering nanoparticles exhibited good bactericidal activity. SiO2 nanoparticle was the most effective on Pg. CaCO3 nanoparticle was the most effective on Aa. The order of the nanoparticle types in which the Pg is most sensitive is SiO2> MgO> Al2O3> ZrO2> CuO> MWCNT> CaCO3. For Aa order is CaCO3> SiO2>MgO> ZrO2> CuO> MWCNT> Al2O3.Conclusion: Our results suggest that engineering nanoparticles have a significant inhibitory effect on Aa and Pg. And, these effects are increased with increasing concentrations of nanoparticles. These results can be further clarified with new studies