The Relationship between Anti-mullerian Hormone and Prolactin Levels in Polycystic Ovarian Syndrome

Abstract

Objectives: This study aimed to investigate serum anti-Mullerian hormone (AMH) and prolactin levels in poly- cystic ovarian syndrome (PCOS) according to the presence of oligomenorrhea. Methods: Women with PCOS who were admitted to an endocrinology outpatient clinic consecutively be - tween January and December 2020 were enrolled in this study retrospectively. The age of the patients includ- ed in this study was between 18 and 40 years. Patients diagnosed with PCOS according to Rotterdam revised criteria. Demographic and clinical characteristics of the patients were obtained from patients’ files. Results: A total of 301 women with PCOS were enrolled in this study. The mean prolactin levels were 20.0±8.5 ng/mL and 22.2±5.5 ng/mL in PCOS patients with and without oligomenorrhea (p=0.091). No significant differ- ences in AMH levels were also found between the two groups 5.3 (5.2–5.4) versus 5.3 3 (5.0–6.0) ng/mL, respec- tively (p=0.798). AMH levels were positively correlated with prolactin and negatively with follicular-stimulating hormone in PCOS subjects (r=0.512, p<0.001, r=?0.155, p=0.007, respectively). The oligomenorrhea group demonstrated increased serum glucose and Vitamin D levels and platelet distribution width value and de - creased glycated hemoglobin, estradiol, free testosterone, hemoglobin, and red cell distribution width values (p<0.001, p=0.017, p=0.018, p=0.001, p=0.008, p=0.027, p=0.001, and p=0.010, respectively). In addition, se - rum prolactin had a relationship between free testosterone and vitamin D levels (r=0.210, p<0.001; r=?0.123, p=0.320, respectively). Conclusion: AMH and prolactin levels did not differ in PCOS patients with and without oligomenorrhea