Biochemical and Histological Characterization of Sorcin Overexpression in Patients Who Underwent Radical Prostatectomy

Abstract

Objective: Sorcin, a signaling molecule, has recently emerged as a significant focus within cancer research. This study aimed to compare histopathology results with serum sorcin level and tissue sorcin immunohistochemical expression in patients who underwent radical prostatectomy (RP). Methods: A total of 81 patients who underwent RP between December 2017 and June 2019 due to prostate cancer (PCa) and had not received any previous treatment were included in the study. Patients attended regular follow-up appointments for at least 24 months. In order to compare serum sorcin levels, the control group consisted of 67 healthy men. Demographic data of participants were recorded. In the PCa group, pathology data from both Transrectal ultrasound-guided biopsy and RP were documented. Results: Prostate-specific antigen (PSA) and sorcin levels of PCa patients were found to be higher than the control group (P < .001, P = .02). In the comparison of sorcin levels and sorcin staining percentages of PCa patients with histopathological and clinical findings; while sorcin levels were found to be higher in patients with positive lymph nodes (P = .018) and with biochemical recurrence (P = .049), no significant difference was found in any histopathological finding in terms of sorcin staining percentages. In an receiver operating characteristic curve analysis calculation for sorcin levels in PCa patients, AUC = 0.563 and when the cut-off value was taken as 0.415 ng/mL, 59.3%sen-sitivity 60.1% specificity was determined. Conclusion: Sorcin was found to be higher in PCa compared to healthy males. In addition, high International Society of Urological Pathology grade groups were observed in patients with high sorcin levels.