Can Pentraxin-3 be a Candidate Marker in the Follow-Up of the Patients With Behcet's Disease?

Abstract

Objectives: This study aims to assess the level of pentraxin-3 (PTX-3) as an inflammatory marker and compare it with C-reactive protein (CRP) levels in patients with Behcet's disease (BD). Patients and methods: Forty-two patients with BD (15 males, 27 females; mean age 39.7 +/- 8.6 years; range 20 to 64 years) and 42 age-and sex-matched healthy controls (14 males, 28 females; mean age 40.8 +/- 8.2 year; range 25 to 60 years) were included in the study. Serum CRP and plasma PTX-3 levels were measured. Subgroup analyses were performed according to clinical manifestations of patients with BD. Results: Both PTX-3 and CRP levels were significantly higher in patients with BD than controls (1.33 +/- 0.29 vs 0.85 +/- 0.12, p< 0.05 for PTX-3 and 0.71 +/- 0.13 vs 0.27 +/- 0.03, p< 0.001 for CRP, respectively). Area under the curve was 0.633 +/- 0.062 vs 0.729 +/- 0.05, respectively. Mean PTX-3 and CRP levels were 1.1 vs 1.5, p=0.5; 0.5 vs 0.9, p= 0.5; respectively, in patients with mucocutaneous involvement alone and with other involvements, whereas they were 0.9 vs 1.6, p=0.1; 0.5 vs 0.8, p=0.3; respectively, in patients with and without peripheral arthritis, and were 1.7 vs 0.9, p=0.06; 1.0 vs 0.5, p=0.07; respectively, in patients with and without uveitis. Conclusion: Although PTX-3 levels were higher in patients with BD than healthy controls, sensitivity and specificity of PTX-3 was not different than CRP in patients with BD.