Colchicine Treatment in Children With Familial Mediterranean Fever: Is it a Risk Factor for Neuromyopathy?

Abstract

BACKGROUND: We cared for a 17-year-old adolescent with familial Mediterranean fever under colchicine treatment. Because of the increased creatinine kinase level (3937 U/L) observed in this individual, we planned to assess all pediatric patients with familial Mediterranean fever under colchicine treatment to detect any resultant neuromyopathy. METHODS: The study included 88 children with familial Mediterranean fever who were receiving colchicine. The patient with myopathy was not included in the study. Serum creatinine kinase levels were measured and nerve conduction studies were carried out in all patients. RESULTS: The study included 88 patients (47 female, 53.4%) with an average age of 10.1 +/- 3.35 years. The average period of colchicine use was 28.25 +/- 17.66 months. Side effects of colchicine were detected in 10 patients (11%)-as diarrhea in eight patients, leukopenia in one patient, and hair loss in one patient. Nerve conduction studies determined incidental carpal tunnel syndrome in only one patient. CONCLUSIONS: Our study did not suggest an elevated risk of neuromyopathy associated with the use of colchicine for familial Mediterranean fever.