Prognostic Significance of C-Reactive Protein and Neutrophil- Lymphocyte Ratio in Lung Adenocarcinoma Patients

Abstract

Objectives: Lung adenocarcinoma (LAC) is the most common subtype of lung cancers. The prognostic value of C- Reactive Protein (CRP) and Neutrophil-Lymphocyte Ratio (NLR) in different types of cancer were reported. There is no clear information about the prognosis in association with the markers, and there are few studies for prognosis in lung cancer. For this reason we investigated CRP and NLR for prognosis in the patients with LAC. Methods: Medical records of 294 pre-treatment LAC patients without any signs or symptoms of an infection who were admitted to the Oncology Outpatient Clinic between 2016-2019, were retrospectively analyzed. Patients were divided into three groups; local, locally advanced, metastatic considering disease course. CRP and NLR values were scanned. The relationship between disease stage, metastases, age, gender, comorbidities, smoking and family history of cancer with survival were evaluated. Results: Deceased patients in all three groups had significantly higher CRP and NLR values (p<0.01). Prognosis and survival in LAC patients may be predicted via both CRP and NLR measurements. Conclusion: We conclude that both of the two markers are reliable with significant distinction of CRP.