Pregnancy in Parkinson's Disease with Levodopa and Pramipexole Exposure

Abstract

Parkinson's disease is a common neurodegenerative disease that rarely occurs in young people. Therefore, cases where pregnancy and Parkinson's disease occur together are very rare and pregnant patients receiving anti-Parkinsonian therapy are rarely presented as case reports in the literature. We report a case of a 36-year-old pregnant woman with a 5 year history of early onset Parkinson's disease who was exposed to levodopa/benserazide plus pramipexole treatment during the first 8 weeks, and levodopa/benserazide treatment until the 37th gestational week. The patient was followed up by the perinatology specialist at regular intervals throughout her pregnancy. No fetal anomaly was detected in the follow- ups. She gave birth to a healthy baby girl by an uncomplicated cesarean delivery. Evidence based data on the most appropriate treatment of Parkinson's disease in pregnancy have not been found in the literature. Larger studies are needed on this subject.