Organizing Pneumonia: Three Case Reports

Abstract

Organizing pneumonia is characterized histopathologically by the accumulation and proliferation of fibroblasts, myofibroblasts and collagen within the alveolar and bronchiolar lumens, with such potential causes as drug reactions, radiation therapy, collagen vascular diseases and infections. In cases with a specific cause, the condition is referred to as secondary organizing pneumonia, and cryptogenic organizing pneumonia when no cause is apparent. Radiologically, nodules or mass lesions accompanied by air bronchograms may be observed together with patchy peripheral alveolar consolidations. Although not present in every case, the reverse halo sign is an important radiological finding. While clinical-radiological diagnosis is possible, it must be confirmed histopathologically. When steroids appropriate dosages and durations are applied, the results are usually outstanding.