Multispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivative

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dc.authorid0000-0002-0064-8400
dc.authorid0000-0003-1405-2920
dc.contributor.authorOzkan, Sule
dc.contributor.authorTaskin-Tok, Tugba
dc.contributor.authorUzgoren-Baran, Ayse
dc.contributor.authorAkbay, Nuriye
dc.date.accessioned2025-05-10T19:55:18Z
dc.date.issued2019
dc.departmentİstanbul Medeniyet Üniversitesi
dc.description.abstractMode of interaction of a new tetrahydrocarbazole derivative with ct-DNA has been investigated systematically using fluorescence spectroscopy, UV-Vis spectroscopy and circular dichroism spectroscopy. It is concluded that TAH could intercalate into the base pairs of ct-DNA, and the fluorescence quenching by ct-DNA was static quenching type. Beside the multispectroscopic results, computational studies were done. Molecular docking results revealed that the TAH-DNAs complexes might be classified as druggable molecule in drug design. Additionally, DNA binding studies exhibited that TAH complexes have different interaction and orientation abilities to each DNA isomer. Combination of experimental and computational data showed that reported TAH is promising structure and deserves further applications.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [114Z391]
dc.description.sponsorshipThis work was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) - Grant No 114Z391.
dc.identifier.doi10.1007/s10895-018-2314-4
dc.identifier.endpage110
dc.identifier.issn1053-0509
dc.identifier.issn1573-4994
dc.identifier.issue1
dc.identifier.pmid30361860
dc.identifier.scopus2-s2.0-85055929660
dc.identifier.scopusqualityQ3
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.1007/s10895-018-2314-4
dc.identifier.urihttps://hdl.handle.net/20.500.14730/13302
dc.identifier.volume29
dc.identifier.wosWOS:000462475000010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofJournal of Fluorescence
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250302
dc.subjectFluorescence
dc.subjectct-DNA
dc.subjectTetrahydrocabazoles
dc.subjectStern-Volmer
dc.subjectGroove binding
dc.titleMultispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivative
dc.typeArticle

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