The correlation of perineural invasion with biochemical recurrence and negative pathological features in prostate adenocarcinoma

Abstract

Introduction: perineural involment is regarded as a significant pathological feature in many organ cancers and a poor prognosis symptom for most of these cancers. In this study, our aim was to analyze the significance of perineural invasion independently from factors such as preoperative Gleason score and clinical, and with regard to biochemical recurrence that occurs after radical prostatectomy. Materials and Methods: The study analyzed 150 prostate cancer cases that underwent radical prostatectomy. The patients received postoperative follow-ups every 3 to 6 months during the first 2 years. The study employed univariate and multivariate analyses to identify any correlation between perineural invasion and surgical margin, Gleason score, extraprostatic extension, seminal vesicle invasion, and biochemical recurrence. The analysis also incorporated the Student T Test, ChiSquare Test, Logistic Regression Test, and SPSS. Results: While the study identified biochemical recurrence in 60 (40.0%) patients, perineural invasion positivity was observed on 96 (64.0%) patients. When the univariate analysis examined the relation of variables to biochemical recurrence, the results indicated that biochemical recurrence was related to positive surgical margin, high Gleason score, seminal vesicle invasion, perineural invasion, high clinical stage, extraprostatic extension, and young age. The results of the logistic regression indicated that Gleason score and clinical stage were independent risk factors of biochemical recurrence. Analysis perineural invasion’s relation with negative pathological features revealed perineural invasion as an independent risk factor for positive surgical margin and seminal vesicle invasion in multivariate analysis. Conclusions: In the cases with perineu-ral invasion, our study found that positive surgical margin, seminal vesicle invasion, extraprostatic extension, and biochemical recurrence occur. © 2015, Ediciones Medicas del Sur S.R.L.. All rights reserved.