A Rare Cause of Recurrent Pneumonia: Common Variable Immunodeficiency

Abstract

Common Variable Immunodeficiency (CVID) is a rare underlying cause of frequent recurrent pneumonia in adults. The primary pathophysiology of CVID is impaired antibody response to the antigens associated with immunoglobulin deficiency, resulting from B lymphocyte pathologies. Frequent recurrent upper and lower respiratory tract infections, accompanying autoimmune comorbidities, and significant associations with malignancies make the early diagnosis and treatment of the condition crucial. We present here the case of a 68-year-old patient diagnosed with CVID following etiological investigations for recurrent pneumonia, discussed in the context of the current literature.