Metastasis in renal cell carcinoma: Biology and implications for therapy

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dc.contributor.authorGong, Jun
dc.contributor.authorMaia, Manuel Caitano
dc.contributor.authorDizman, Nazli
dc.contributor.authorGovindarajan, Ameish
dc.contributor.authorPal, Sumanta K.
dc.date.accessioned2025-05-10T19:48:28Z
dc.date.issued2016
dc.departmentİstanbul Medeniyet Üniversitesi
dc.description.abstractAlthough multiple advances have been made in systemic therapy for renal cell carcinoma (RCC), metastatic RCC remains incurable. In the current review, we focus on the underlying biology of RCC and plausible mechanisms of metastasis. We further outline evolving strategies to combat metastasis through adjuvant therapy. Finally, we discuss clinical patterns of metastasis in RCC and how distinct systemic therapy approaches may be considered based on the anatomic location of metastasis. (C) 2016 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.
dc.description.sponsorshipPfizer; Novartis; Aveo; Genentech; Exelixis; BMS; Astellas; GSK
dc.description.sponsorshipDr. Pal receives honoraria from Novartis, Medivation and Astellas Pharma, and receives consulting fees from Pfizer, Novartis, Aveo, Genentech, Exelixis, BMS, Astellas and GSK.
dc.identifier.doi10.1016/j.ajur.2016.08.006
dc.identifier.endpage292
dc.identifier.issn2214-3882
dc.identifier.issn2214-3890
dc.identifier.issue4
dc.identifier.pmid29264197
dc.identifier.scopus2-s2.0-85027839647
dc.identifier.scopusqualityQ2
dc.identifier.startpage286
dc.identifier.urihttps://doi.org/10.1016/j.ajur.2016.08.006
dc.identifier.urihttps://hdl.handle.net/20.500.14730/11702
dc.identifier.volume3
dc.identifier.wosWOS:000390819500015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Singapore Pte Ltd
dc.relation.ispartofAsian Journal of Urology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250302
dc.subjectRenal cell carcinoma
dc.subjectMetastasis
dc.subjectVascular endothelial growth factor
dc.subjectMammalian target of rapamycin
dc.subjectHypoxia inducible factor
dc.titleMetastasis in renal cell carcinoma: Biology and implications for therapy
dc.typeReview

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