Role of the oxidative stress index, myeloperoxidase, catalase activity for cardiac allograft vasculopathy in heart transplant recipients

Abstract

BackgroundThe aim of this study was to explore the role of oxidative stress index (OSI), myeloperoxidase (MPO), and catalase (CAT) activity in cardiac allograft vasculopathy (CAV) in heart transplant recipients (HTRs). MethodsThe study enrolled a median age of 419years 47 recipients. The HTx patients were divided into two groups based on the presence CAV as follows: CAV((+)) and CAV((-)) group. Also, CAV((+)) group were divided into two groups as mild/moderate to severe CAV. The OSI, MPO, and CAT activity were analyzed in both groups. ResultsThe mean total antioxidant capacity (0.79 +/- 0.46 vs 1.03 +/- 0.33mol H2O2 equiv/L) P=.043 was significantly lower and OSI, MPO, CAT activity were significantly higher in CAV((+)) group (63 +/- 38 vs 20 +/- 16 arbitrary unit, P=.001; 398 +/- 242 vs 139 +/- 112g/L, P=.001; 51 +/- 42 vs 26 +/- 23pmol/mg protein, P=.013, respectively). Also, mean OSI (38 +/- 41 vs 93 +/- 75, P=.05) were significantly higher in severe CAV((+)) group. Recipient age, male gender, and low density lipoprotein-cholesterol were significantly higher in CAV((+))group. There was a moderate correlation between the CAV grade and OSI, MPO, and CAT levels in univariate analysis (r=.560, P=.002; r=.643, P=.007; r=.681, P=.001, respectively). ConclusionAn increase in the serum level of OSI, MPO, and CAT was associated with CAV in HTRs.