The Relationship Between the Prognostic Nutritional Index and Overall Survival in Elderly Patients with Epithelial Ovarian Cancer

Abstract

Objectives: Ovarian neoplasm is the most common cause of mortality in gynecologic malignancies. In this study, weaimed to investigate the prognostic role of pretreatment prognostic nutritional index (PNI) in geriatric Turkish femalepatients with advanced epithelial over cancer.Methods: We retrospectively collected the data of 116 elderly ovarian cancer patients who treated between 2008 and2019. The PNI was calculated as following: [(10×serum albumin (g/dL)) + (0.005×total lymphocyte count)].Results: The median PNI was 44.8. Median OS was 45 months (95% CI: 31.6–58.3) in patients with PNI ?44.8, 79 months(95% CI: 77.6–80.3) in patients with PNI >44.8 (p=0.002). In cox regression analysis, PNI was found to be an independentprognostic factor as affecting overall survival.Conclusion: From this point of view, it may be considered that nutritional status should be evaluated more prominentlyfor predicting prognosis in geriatric population.