MONOCYTE TO HDL-CHOLESTEROL RATIO IN MALE WITH HYPOGONADOTROPIC HYPOGONADISM

Abstract

INTRODUCTION: Previous studies have shown that idiopathichypogonadotropic hypogonadism (IHH) patients with lowtestosterone levels lead to an impaired glucose metabolism and anincreased cardiovascular risk. Monocyte to high-density lipoproteincholesterol (HDL-C) ratio (MHR) also has been shown to be anindicator of inflammation and cardiovascular risk. The purpose ofthe present study is to investigate MHR in the male with IHH.MATERIAL AND METHODS: This study includes 31 men withIHH without previous treatment for the disease and 44 healthymen. The blood samples, anthropometric measures, and physicalexamination were undertaken by all the participants.RESULTS: Mean ages of the IHH patients and the healthy controlswere 22.5±7.2 years vs. 22.9±6.4 years. There was no statisticallysignificant difference between the patients and controls in termsof the mean HDL-C, mean monocyte count, and mean MHR.The MHR also was not correlated with the other hematologicalparameters, inflammatory parameters, and the total testosteronelevel.CONCLUSION: MHR has been shown to be an indicator ofcardiovascular risk in previous studies but we could not detect anincreased MHR value in patients with IHH in this study.