Evaluation of the Relationship Between Luteinizing Hormone Levels and Body Mass Index in Girls With Idiopathic Central Precocius Puberty

Abstract

Objective: Excess adiposity has effects on various aspects of pubertal development as the timing of pubertal initiation and hormonal parameters during puberty. We aimed to determine the effect of BMI on peak LH (luteinizing hormone) levels obtained by standard GnRH (Gonadotropin Releasing Hormone) stimulation test in girls with central precicous puberty. Materials and Methods: A total of 59 female patients who were diagnosed as idiopathic central precicous pubertywere included in the study. Anthropometric measurements at the time of GnRH stimulation test and basal/stimulated gonadotropin levels were evaluated. The relationship between BMI and gonadotropins was investigated. Results: The mean age of the participants was 7.11±1.01 (3.20-7.94) years. 21 cases(35 %) were overweight/obese. 67.8% (n = 40) of the cases were presented with breast development and 64.4% (n = 38) were in stage 2, 35.6% (n = 21) were in stage 3 puberty. There was no significant correlation between BMI SDS and basal/peak LH levels (p=0.531, p= 0.598 for stage 2 and p=0.126, p=0.827 for stage 3 puberty respectively), peak LH / FSH (follicle-stimulating hormone)ratio (p=0.408 for stage 2 and p=0.797 for stage 3 puberty) in patients according to both puberty stages. There was not also any correlation between BMI /BMI SDS and peak LH in total study group.Basal LH, FSH, E2 and peak LH levels did not vary among normal weight, overweight and obese cases. Conclusion: Body mass index had no effect on basal and stimulated gonadotropin levels in girls with central precicous puberty in different stages of puberty.