OXIDATIVE IMBALANCE IN AUTOIMMUNE LIVER DISEASE: EVALUATION OF OXIDANT-ANTIOXIDANT STATUS AND ISCHEMIA-MODIFIED ALBUMIN

Abstract

ObjectiveCurrent study evaluated the utility of total antioxidantstatus (TAS), oxidative stress index (OSI), total oxidant status (TOS), ischemia-modified albumin (IMA),and ischemia-modified albumin ratio (IMAR) as markers in autoimmune liver disease (AILD).Material and MethodsThe study included a total of 66 AILD patients, 22 withautoimmune hepatitis (AIH), 32 with primary biliarycholangitis (PBC), and 12 with AIH/PBC overlap syndrome, and 49 healthy controls. Serum TAS, TOS,and IMA levels were analyzed. OSI was calculated asTOS/TAS and IMAR was derived from IMA and Alb.ResultsSerum TAS, OSI, TOS, IMA, and IMAR values werefound to be significantly higher in the AILD group compared to controls (p=0.004, <0.001, <0.001, <0.001,and <0.001, respectively). Cut-off values of TOS,IMA, and IMAR for the prediction of AILD were 4.1?mol H2O2 equiv./L, 0.522 absorbance unit (ABSU),and 0.520 ABSU, respectively. Area under the receiver operating characteristic curves for TOS, IMA, andIMAR was 0.760, 0.830, and 0.858, respectively.ConclusionOur findings demonstrated the presence of oxidativestress in AILD and the utility of the related markers forits differentiation.