Monocyte to HDL cholesterol ratio and its association with cardio-metabolic risk factors in primary hyperparathyroidism

Abstract

The monocyte count to HDL-Cholesterol ratio (MHR) has been shown as a novel prognostic indicator of cardiovascular diseases. Several studies demonstrated that even mild primary hyperparathyroidism (PHPT) has an increased risk for cardiovascular disease. We aimed to evaluate MHR and its relation with cardio-metabolic risk factors in patients with PHPT. Seventy-five patients with PHPT and 96 control subjects were included in the study. Demographic, anthropometric, and biochemistry results were recorded. The groups were compared in terms of monocyte counts, HDL-cholesterol (HDL-C), and MHR values. Correlation analysis was used to determine the relation between MHR and cardio-metabolic parameters. The mean age was similar in each group (52.69±10.91 to 53.33±7.70 years, p=0.667). Sex distribution and body mass index were similar in each group (p>0.05). Monocyte counts and HDL-C levels were similar in each group (479.73±136.97 vs 500.13±144.06 and 51.54±11.99 vs 51.95±11.66 mg/dL, p>0.05). MHR was similar between groups (9.71±3.65 vs 10.11±3.86, p>0.05). MHR was positively correlated with systolic blood pressure (SBP) and homeostasis model assessment of insulin resistance (HOMA-IR) (r2=0.276, p=0.019 and r2=0.271, p=0.020, respectively). There was no association between MHR and other cardio-metabolic risk factors including diastolic blood pressure (DBP), carotid intima media thickness (CIMT), and c-reactive protein (CRP) (p>0.05). The MHR did not increase in patients with PHPT. The MHR was correlated with SBP and HOMA-IR; however, it was not associated with other cardio-metabolic risk factors including DBP, CIMT, and CRP. © 2018, Logos Medical Publishing. All rights reserved.