Evaluation of Serum, Saliva and GCF Visfatin Levels in Chronic Periodontitis Patientswith Uncontrolled /Controlled Type2 Diabetes Mellitus

Abstract

Background: The aim of this study is to investigate visfatinlevels in serum, saliva and GCF samples of non-diabetic CPpatients, CP patients with t2DM and ut2DM, and to evaluateof the relationship with clinical and biochemical parameters ofCP. Methods: Study protocol, 5 groups which each one wereconsisted of 15 subjects were planned: patients with bothperiodontal and systemic health (DM-P-); CP patients withsystemic health (DM-P+), periodontally healthy patients withdiabetes (DM+P-), patients with diabetes and CP (DM+P+),patients with uncontrolled diabetes and CP (uDM+P+).Serum, saliva and GCF samples were collected and levels ofvisfatin, TNF-? and IL-1? were determined by ELISA. Results: The highest levels of visfatin, TNF-? and IL-1? wereseen in (uDM+P+) group (p>0.001). Significant positivecorrelations between GCF visfatin levels and GCF TNF-? andIL-1? levels were detected in (uDM+P+) group (p<0.001). Conclusion: Serum, saliva and GCF visfatin levels werehighest in the uncontrolled diabetes group. Different studiesare needed to clarify the effect of visfatin on glycemic controlin patients with diabetes and its relationship with periodontaldisease.