Quercetin/?-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

Basit Öğe Kaydı
dc.authorid0000-0002-0639-5862
dc.contributor.authorAytac, Zeynep
dc.contributor.authorKusku, Semran Ipek
dc.contributor.authorDurgun, Engin
dc.contributor.authorUyar, Tamer
dc.date.accessioned2025-05-10T19:49:27Z
dc.date.issued2016
dc.departmentİstanbul Medeniyet Üniversitesi
dc.description.abstractElectrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating beta-cyclodextrin inclusion complex (beta-CD-IC) of quercetin (QU) was performed. Here, beta-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/beta-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/beta-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/beta-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/beta-CD-IC-NF was much slower but greater in total than from PAA/QU/beta-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/beta-CD-IC-NF. (C) 2015 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [111M459]; Turkish Academy of Sciences - Outstanding Young Scientists Award Program (TUBA-GEBIP); TUBITAK [111M459, 213M185]
dc.description.sponsorshipThis work is supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project # 111M459). Dr. Uyar and Dr. Durgun acknowledge partial support from The Turkish Academy of Sciences - Outstanding Young Scientists Award Program (TUBA-GEBIP). Z. Aytac thanks to TUBITAK (project # 111M459 and #213M185) for the PhD scholarship.
dc.identifier.doi10.1016/j.foodchem.2015.11.051
dc.identifier.endpage871
dc.identifier.issn0308-8146
dc.identifier.issn1873-7072
dc.identifier.pmid26617028
dc.identifier.scopus2-s2.0-84947460328
dc.identifier.scopusqualityQ1
dc.identifier.startpage864
dc.identifier.urihttps://doi.org/10.1016/j.foodchem.2015.11.051
dc.identifier.urihttps://hdl.handle.net/20.500.14730/12039
dc.identifier.volume197
dc.identifier.wosWOS:000366985900112
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofFood Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250302
dc.subjectElectrospinning
dc.subjectNanofibres
dc.subjectPolyacrylic acid
dc.subjectQuercetin
dc.subjectbeta-Cyclodextrin
dc.subjectModelling
dc.subjectPhase solubility
dc.subjectAntioxidant activity
dc.subjectPhotostability
dc.titleQuercetin/?-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility
dc.typeArticle

Dosyalar

Orijinal paket

Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
12039.pdf
Boyut:
1.43 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu