The impact of diabetes on left ventricular diastolic function in patients with arterial hypertension

Abstract

OBJECTIVE: The aim of this study is to analyse the impact of diabetes mellitus on the left ventricular diastolic function in patients with arterial hypertension. METHODS: Between July 2007 and July 2008, we enrolled patients aged >= 40 years who had hypertension with or without type 2 diabetes mellitus and unknown history of coronary artery disease who applied to 7.-8. internal medicine polyclinics of Goztepe Education and Training Hospital. Transthoracic echocardiography was used to assess the diastolic function. If patients with positive treadmill exercise test and/or EF <=%50 in transthoracic echocardiography were excluded from the study. A total of 110 patients (males, n = 42 38.2%, and females, n = 68; 61.8%) with a mean age of 60.78 (+/- 10.627) years were included in the study. For statistical analysis, SPSS 12.0 program and for the comparison of data chi-square test was used. RESULTS: Diastolic dysfunction was significantly more prevalent in diabetes (81.25%) than those without diabetes group (62.9%) (p<0.05). In men, 35.9% in the DM(+) group and 41.1% in the DM(-) group had diastolic dysfunction. In women, 64.1% in the DM(+) group and 58.29% in the DM(-) group had diastolic dysfunction. In the evaluation based on gender, the difference male and female patients was not significant (p>0.05). CONCLUSION: Diabetes in association with hypertension has a negative effect on left ventricular diastolic function. This effect appears similar in men and women.